Abstract
In a model of ARDS in adult rabbits, we have compared the capacity of exogenous synthetic surfactant, administered by bolus or by lavage, to reexpand the lungs and to inhibit the inflammatory process. The surfactant used contained DPPC and POPG (3:1) together with palmitic acid (15% by weight) and the peptide KLLLLKLLLLKLLLLKLLLLK (KL4) that mimics SP-B.1 This surfactant preparation, termed KL4-surfactant, has been evaluated in animal studies2 and a clinical trial in 47 patients with idiopathic respiratory distress syndrome.
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