Abstract
Surface treatment of acetylsalicylic acid (ASA) crystals was examined in a Wurster fluid bed system with water-soluble and water-insoluble lubricants. The influence of the coating process on the flowability, the compressibility and the dissolution rate of the crystals was studied, and the results were compared with the corresponding parameters of ASA crystals processed by a conventional (mixing) method. The coating materials were Carbowax® 6000 as water-soluble and stearin as water-insoluble lubricant. The control sample was unprocessed (commercial) ASA crystals. The Strea-l fluid bed coater with the Wurster column could be used for the production of a lubricant coating on crystal surfaces. The coated crystals, in comparison with mixed samples, had very good compactibility, cohesivity and compressibility values. Their lubrication coefficient was higher and the friction work was less than those of mixed crystals. The dissolution of the active agent could be regulated by the lubricant coat. The rate of dissolution of ASA was primarily promoted by a film coat of Carbowax® 6000 from a capsule.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
