Abstract
We report a methodology to functionalize the bare copper grids for high resolution transmission electron microscopy (TEM), by drop casting a thin polymer film instead of carbon film. The polymer coating actively helped in trapping the sample on the top of the mesh, making it available for the imaging. Gold nanorods (AuNRs), poly(allylamine) hydrochloride (PAH)/dextran sulphate (DS) nanocapsules and PAH/DS nanocapsules incorporated with AuNRs, were used as samples on the bare grids, carbon-coated grids and polymer-coated grids. The effect of polymer charge, polymer concentration and film thickness on imaging quality was studied using different polymers such as chitosan, PAH, polystyrene sulfonate, DS and gellan gum. The polymer-coated copper grids showed a comparable performance with the conventional carbon-coated copper grids. Hence, the methodology provides a simple and economical way to obtain high quality TEM images using the bare copper grids.
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