Abstract
For the avoidance of severe immune reactions and short-circuiting of implantable electrical devices caused by conductive soft tissues, it is essential to encapsulate these devices with biocompatible materials. However, existing packaging materials such as PET often confront the problem of hydrophobic surfaces that are unable to adhere well to biological tissue, causing inflammatory response and displacement. To solve the problem, we endeavor to modify the surface of the packaging material PET in order to increase its biocompatibility and reduce the hydrophobicity for cell adhesion. Herein, we covalently bond RGD to SF modified PET film instead of directly adsorption of SF and RGD onto PET surface, PC-12 cells show enhanced adhesion ability to the surface and could produce multiple pseudopods, which further significantly improves their extension and proliferation behavior. This modification strategy provides an effective way for the preparation of biocompatible electronic packaging materials.
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