Abstract
Results GMS nVP auNPs with > 75% entrapment efficiency & 85% binding to the ligand. In cytotoxicity study nanoformulations showed higher cell viability at all time points as compared to NVP. Cell uptake study revealed higher uptake of nanoparticles as compared to NVP only. In vitro anti HIV assay of surface modified revealed 10 fold increased activity as compared to NVP.
Highlights
The therapeutic efficacy of nevirapine (NVP) is hampered by its poor solubility; poor ability to target infected cells and inherent toxicity
Surface functionalization of GMS nVP auNPs was studied by fluroscence spectrophotometry
NVP were evaluated for cytotoxicity
Summary
Surface functionalized nanoparticles of NVP an improved strategy to tackle deadly HIV infection. Bhagyashree R Dalvi1*, Shilpa M Velhal[2], Atmaram B Bandivadekar[2], Absar Ahmad[3], Padma V Devarajan[1]. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. 30 January - 1 February 2014
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