Abstract
This article proposes a new method for sample preparation via synthesis of a sorbent based on silica gel functionalized with ionic liquid. Ionic liquids (ILs) have a great potential for application in extraction techniques as they can interact by hydrophobic and π–π interaction. Thus ionic liquid-modified silica [SiO2-MIM-BF4−] adsorbent was proposed for isolation of fatty acids such as docosahexaenoic, eicosapentaenoic and arachidonic acid. The main goal and novelty of this research was the application of the developed adsorbent to human milk analysis. In an application study, the synthesized adsorbent was used in dispersive solid phase extraction in combination with liquid chromatography coupled with evaporative light scattering detector. The linear range for the ELSD concentration response was wider (135–1626 µg/mL) for polyunsaturated fatty acid methyl esters. The recovery study demonstrated recovery between 67% and 78% for specific acids with relative standard deviation lower than 6%.
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