Abstract
Supplementation with fish oil improves life quality, and decreases inflammatory status and oxidative stress in psoriasis
Highlights
Psoriasis is an immune-mediated hyperproliferative chronic inflammatory skin disease affecting about 1.3-2.2% of the world population [1]
No statistically significant changes between the groups were observed in any anthropometric, inflammatory biomarker, cell adhesion molecules or oxidative stress at the baseline (Table 2, Figures 1and 2)
The main finding of this study was that fish oil n-3 fatty acids was able to decrease the oxidative stress and increase antioxidant capacity in patients with psoriasis after 3 months of supplementation
Summary
Psoriasis is an immune-mediated hyperproliferative chronic inflammatory skin disease affecting about 1.3-2.2% of the world population [1]. The interaction among keratinocytes, neutrophils, mast cells, T cells, and dendritic cells is thought to create inflammatory and pro-proliferative circuits mediated by chemokines and cytokines, which induce the development of psoriatic lesions, clinically characterized by sharply demarked, erythematous, and scaly plaques [1]. The increased levels of malonaldehyde (MDA) associated with decreasing plasma β-carotene, reduced glutathione (GSH) and α-tocopherol (vitamin E) were found in plasma and erythrocytes of psoriatic patients [4], as well as a decreased erythrocytes antioxidant activity verified by decreasing in catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities [5,6]. The high level of MDA indicates an advanced peroxidative process in erythrocyte membranes, suggesting that increased peroxidation caused by decreasing in the levels of the antioxidants and antioxidant enzyme activities may be the essential
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