Abstract

<p>Copy number plots from two pre-treatment HERACLES A samples. X axis represents chromosome (chr) number across the Guardant360 genomic footprint. Y axis represents observed copy number in plasma. Colored dots represent probe-specific copy number signals at each chromosomal position and light green horizontal line represents the sample-specific normalized diploid copy number. The 18 reported gene amplifications are labelled, including ERBB2 on chromosome 17. The sample represented in panel 2A is suggestive of chromosome 17 aneuploidy, as all 5' probe specific signals adjacent to and including ERBB2 are increased (ERBB2 observed pCN = 52.8). In contrast, panel 2B shows clear focal amplification of ERBB2 only (ERBB2 observed pCN = 7.7).</p>

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.