Abstract
1. In the isolated frog spinal cord perfused with kainic acid (KA, 5 × 10 −4M) containing Ringer's solution, within 2 hr there were increases in the amplitude of the dorsal root depolarization, as induced by the GABA-agonists. 2. KA perfusion produced increases in the specific binding of [ 3H]muscimol to crude synaptic membranes and incubation with KA for 3 hr did not increase [ 3H]muscimol binding. 3. [ 3H]GABA was released from KA-treated spinal cord slices in the presence of high K +. 4. KA-induced supersensitivity of the dorsal root to GABA may relate to direct actions on primary afferent terminals and not to denervation of GABAergic neurons.
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