Abstract

Assisted reproductive technology (ART) is associated with adverse perinatal outcomes including abnormal placentation, low birth weight, and hypertensive disorders of pregnancy. These effects are thought to be due to disrupted endometrial angiogenesis and placental vasculogenesis in response to differential effects of ovulation triggers [human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone agonist (GnRHa)] on the endometrial immune microenvironment; especially natural (NK) cells.

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