Abstract
Superhydrophobic silver films were fabricated by silver-mirror reaction and surface functionalization with thiol. The thiol-functionalization significantly improved the hydrophobic property of the Ag films (AFS), and their contact angle values slightly increased with the extension of a thiol alkyl chain, reaching about 160°. The surface-enhanced Raman scattering (SERS) detection capacity of these films were investigated, and AFS-Dodec showed the best substrate for R6G molecule detection with the concentration limit of 10-11 M. AFS functionalized with dodecanethiol (AFS-Dodec) was applied for the SERS detection of uric acid and creatinine, it exhibited good linear dependence relationship between the Raman intensity and analyte concentration in the concentration range of 5~1000 μM.
Highlights
Uric acid is a metabolite considered as an inert end-product of purine catabolism, its concentration in blood is determined by the balance between uric acid production and excretion
It is generally regarded that Surface-enhanced Raman scattering (SERS) enhancement stems from two mechanism [10,11]: One is chemical enhancement, which is realized by charge transfer between the analytes and the SERS substrate; the other is electromagnetic enhancement, which plays the dominant role in SERS enhancement [12,13]
Modification is an effective way to prepare hydrophobic surfaces, Ag films (AFS) was functionalized with a series of organic thiols to improve its hydrophobic property
Summary
Uric acid is a metabolite considered as an inert end-product of purine catabolism, its concentration in blood is determined by the balance between uric acid production and excretion. It is identified as an important biomarker in urine and serum samples for metabolism abnormally, strong correlated of renal dysfunction in rheumatoid arthritis cardiovascular [1,2] and gout disease [3]. The common SERS substrates have hydrophilic surface, which makes the analyte solution spread over the whole surface, resulting in the low detection limit even with high density-hotspots. The hydrophobic substrate can cause great shrinkage of the solution during the solvent evaporation process, and the analyte molecules are concentrated to a smaller size and increase their density, which enables more analyte molecules to be exposed to laser spot, resulting in high detection selectivity
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