SUN-282 INCREASE LEVEL OF TNF-α NOT CORRELATED WITH TOTAL ANTIOXIDANT CAPACITY ON CHRONIC KIDNEY DISEASE PATIENTS STAGE 3-5

Abstract

CKD patients showed higher level of inflammation such as TNF-α and oxidative stress that result in an imbalance between free radical production and antioxidant defenses. Total antioxidant capacity (TAOC) is a parameter of combined antioxidant defenses in biological fluids. There are only few information about association between total antioxidant capacity (TAOC) and TNF-α. This is an observational analytic study on 80 chronic kidney disease patients stage 3-5. CKD staging of eGFR was measured by CKD-EPI. Blood samples was then measured for total antioxidant capacity (TAC) and TNF-α. Correlation between TAOC and TNF-α was measured with Rank-Spearman There were 21 patients on stage 3, 20 patients on stage 4 and 39 patients on stage 5 CKD. There were no significant difference of TAOC among CKD stage 3 to 5 respectively 21,3 ± 10,9;18,3 ± 9,9;20,6 ± 6,9 U/mL with p=0,521 but there were a significant difference of TNF-α among group of CKD stage 3-5 and respectively 2953(1661–9460);3394(1520–8467);3918(1936–17601) pg/mL with p=0,008. TNF-α shows strong negative correlation with eGFR by CKD-EPI (r=-0,383;p=0,000) but there was no correlation between TAC and eGFR (r=-0.119;p=0.146). Statistical analysis using Rank Spearman found that there was no significant correlation between TNF-α level and TAC level (r = 0.127, p = 0.131). Total antioxidant capacity reveals a stagnant level among CKD group 3-5 while the TNF-a level increase among CKD stage 3 to 5 There is no significant correlation between TAC levels and TNF- α. Although there was an increase level of TNF-α but it does not followed by increase capacity of total antioxidant in CKD stage 3-5