Abstract
The effect of sumatriptan 100mg orally on paracetamol absorption was evaluated in 9 migraine patients. Sumatriptan pretreatment significantly lowered the peak paracetamol concentration and also delayed the time to reach peak concentration. The paracetamol peak concentration decreased significantly from 36.28 ± 10.85 mg/L to 18.26 ± 6.7 mg/L, and the time to reach the peak was significantly delayed from 1.36 ± 0.38 hours to 2.72 ± 1.0 hours after sumatriptan treatment. The rate of absorption of paracetamol up to 3 hours was significantly reduced after sumatriptan administration. At 2 hours after sumatriptan administration, only 67% of total paracetamol was absorbed, while the absorption was 97% without sumatriptan. The total absorption of paracetamol at the end of the 8th hour was, however, not affected. These results suggest that in migraine patients there is a delay in gastric emptying time with sumatriptan. Further studies are warranted during the acute attack to elucidate the clinical significance of the present study findings.
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