Abstract
BackgroundIn the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents.MethodsIn a systematic search from PubMed, Scopus, Embase and Cochrane electronic databases up to 20 April 2020, the observational studies that evaluated the association between sugar-sweetened beverages intake and hypertension, systolic or diastolic blood pressure (SBP, DBP) were retrieved.ResultsA total of 14 studies with 93873 participants were included in the current meta-analysis. High SSB consumption was associated with 1.67 mmHg increase in SBP in children and adolescents (WMD: 1.67; CI 1.021–2.321; P < 0.001). The difference in DBP was not significant (WMD: 0.313; CI −0.131– 0.757; P = 0.108). High SSB consumers were 1.36 times more likely to develop hypertension compared with low SSB consumers (OR: 1.365; CI 1.145–1.626; P = 0.001). In dose–response meta-analysis, no departure from linearity was observed between SSB intake and change in SBP (P-nonlinearity = 0.707) or DBP (P-nonlinearity = 0.180).ConclusionsAccording to our finding, high SSB consumption increases SBP and hypertension in children and adolescents.
Highlights
In the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents
In the current systematic review and meta-analysis, we aimed to summarize the studies that evaluated the association between SSBs intake and blood pressure among children and adolescents in twoclass and dose–response meta-analysis
Thereafter 857 manuscripts were remained for full text screening after removing duplicates and exclusion according to the title and abstract reading
Summary
In the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents. Hypertension, as one of the major component of metabolic syndrome is associated with obesity state and has an increasing prevalence in youth [2]. Farhangi et al J Transl Med (2020) 18:344 levels are influenced by genetic as well as by environmental factors [5, 6]. In this regard, more than 90 different genetic polymorphisms have been identified to be associated with high blood pressure [7]. A recent study reported that polymorphism of aldosterone synthase gene is linked with the development of hypertension through increasing the aldosterone level and aldosterone/renin ratio [5]. Among environmental parameters, obesity, smoking, alcohol consumption, diet, and physical inactivity likely play a major role in development of hypertension [6]
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