Abstract
Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles were disclosed for ovalbumin (OVA) delivery system. The mannose-coated polypeptide nanoparticles can induce strongest targeting and immune adjuvant effects to macrophages than those glucose/lactose-coated ones, which effectively transported OVA into cells and facilitated OVA subcellular escape from endolysosomes into cytoplasm with the assistance of UV irradiation or intracellular acidic pH.
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