Abstract
Polymers constitute a group of materials having a wide-ranging impact on modern pharmaceutical technology. Polymeric components provide the foundation for the advancement of novel drug delivery platforms, inter alia orodispersible films. Orodispersible films are thin, polymeric scraps intended to dissolve quickly when put on the tongue, allowing them to be easily swallowed without the necessity of drinking water, thus eliminating the risk of choking, which is of great importance in the case of pediatric and geriatric patients. Polymers are essential excipients in designing orodispersible films, as they constitute the backbone of these drug dosage form. The type of polymer is of significant importance in obtaining the formulation of the desired quality. The polymers employed to produce orodispersible films must meet particular requirements due to their oral administration and have to provide adequate surface texture, film thickness, mechanical attributes, tensile and folding strength as well as relevant disintegration time and drug release to obtain the final product characterized by optimal pharmaceutical features. A variety of natural and synthetic polymers currently utilized in manufacturing of orodispersible films might be used alone or in a blend. The goal of the present manuscript was to present a review about polymers utilized in designing oral-dissolving films.
Highlights
Among the many different routes of drug application (the Food and Drug Administration (FDA) distinguishes about 100 of them), the most preferred and the least invasive is the oral route [1]
The findings demonstrated that, for a lower-molecular-weight polymer (HPMC E5), the higher polymer concentration is necessary to obtain a similar viscosity as the high-molecular-weight polymer
The results showed that ODFs based on Hydroxypropyl methylcellulose (HPMC) E15 demonstrated superior properties when compared to E5 films
Summary
Among the many different routes of drug application (the Food and Drug Administration (FDA) distinguishes about 100 of them), the most preferred and the least invasive is the oral route [1]. The optimal characteristics of polymers used in designing of ODFs include good spreadability, viscoelasticity, biocompatibility, and compliance with a drug The selection of those excipients has to be guided by the desired properties of the ODF such as strength of the film, pliability, dissolution rate and moisture content, non-toxicity, capacity of immediate disintegration upon contact with the Materials 2021, 14, 4872 saliva, sufficient mechanical properties (tensile strength, folding endurance, tear resistance), relevant elasticity, and a structure of ODFs. The mechanical features of the films depend strongly upon the Tg of the cross-linked polymer and upon the degree of cross-linking. It should be emphasized that all the above mentioned polymers have been proven safe for human use [21,22]
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