Abstract
Pharmaceutical emulsions are now given increasing attention because they are widely used in medical practice. This became possible due to a qualitatively new level of scientific research and achievements in the field of emulsion systems creation, as well as expansion of assortment of auxiliary substances and use of new modern equipment. Emulsions are heterogeneous disperse systems that are potentially unstable. Therefore, the issue of stabilizing of emulsion systems is the main problem in area of emulsions technology.Aim. The aim of the experiment was to study structural and mechanical properties of concentrated emulsion systems, depending on the total concentration of surfactants, as well as investigation of colloidal and thermal stability of samples for substantiation of the composition of surfactants in the development of a cream with silver citrate.Methods. Pharmaco-technological methods of research were conducted in accordance with the requirements of the State Pharmacopoeia of Ukraine.Research results. Colloidal and thermal stability of the samples of emulsion cream with silver citrate was investigated. It has been established that the use of emulsifiers in concentrations of 4 % and 6 % does not provide physical stability. A dispersion analysis of the heterogeneous systems was carried out, which has shown that the samples obtained by using of the emulsifiers combination are homogeneous in size of particles of oil phase, which do not exceed 10 microns. The behavior of samples of the emulsion cream with silver citrate during and after mechanical destruction is investigated. The results guarantee stability of the system under the influence of mechanical processing during industrial production and use. Conclusion. As a result of the experiment, the use of the combination of surface-active substances: emulsifier № 1 and cetostearyl alcohol of 8-10 % was used to stabilize the emulsion system with silver citrate
Highlights
Soft medicinal forms are widely used, but emulsion creams, which are homogeneous and consisting of at least two mutually unmixed or partially mixed liquids, are the most widespread
Stabilizersemulsifiers and stabilizers-thickeners are introduced into emulsions; they reduce the interfacial surface tension between two phases, form strong protective coatings on the particles surface, and increase viscosity of the dispersion medium
When selecting emulsifiers for pharmaceutical emulsions, it is recommended to figure on their stabilization mechanism, toxicity, pH, and chemical compatibility with active pharmaceutical ingredients (API)
Summary
Soft medicinal forms are widely used, but emulsion creams, which are homogeneous and consisting of at least two mutually unmixed or partially mixed liquids, are the most widespread. It is necessary to select the emulsifying mixture composition according to the additivity rule in determining the “required” hydrophilic-lipophilic balance (HLB) for oil phase and guided by the theoretical data about the HLB system application, whereby it is recommended to use two surfactants, one of which is characterized by high HLB value, and the second – by low one [13]. To stabilize the oil/water emulsion system, which is used for the present research as a basis for the pharmaceutical development of a cream containing a silver citrate solution, the surfactants such as cetyl stearyl alcohol, glyceryl monostearate, polysorbate-80, and emulsifier No 1 were studied. 5. Formulation of goals (tasks) of Article The aim of the research is to study the structural and mechanical properties of concentrated emulsion systems, depending on the surfactants total concentration, and the study of colloidal and thermal stability of the samples for substantiation of the surfactants composition in the development of the cream with silver citrate. The samples were left for a day to structure the disperse system and they were used for rheological research
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