Abstract
THOUGH previously it has been known that bone marrow contains a hormone-like substance which has an accelerating action upon the blood coagulation1, its chemical nature has remained unclarified. We have now investigated this problem. Bone marrow from long tubular bones of domestic fowls, after removal of lipids with alcohol, acetone and ether, was extracted with physiological saline and then the extract was deproteinized with sulphosalicylic acid. After removal of excess sulphosalicylic acid with calcium carbonate, the filtrate was concentrated to a small volume. This filtrate showed a remarkable accelerating action on the blood coagulation.
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