Abstract
Objective To study the serum substance P (SP) and its role in renal pruritus patients. BackgroundUremic pruritus is a common complication in patients undergoing dialysis. The pathophysiological mechanisms of pruritus in patients with end-stage renal disease remain unknown. Neuropeptides, including SP, are postulated to play an important role in the pathogenesis of pruritus. The aim of this study was to evaluate the role of SP in uremic pruritus in patients.Patients and methodsThis study was conducted according to sample size calculation on 44 renal pruritus patients and 30 sex-matched and age-matched healthy individuals as a control group and were selected by random sample. This was a case–control study.ResultsSP has an important role in renal pruritus as there was a statistically significant difference between the two studied case and control groups (P = 0.001). Also, there was positive correlation between the duration of renal disease and the frequency of pruritus.ConclusionSP may have an important role in renal pruritus patients.
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