Abstract
A novel attenuated total reflection-mid infrared-hollow optical fiber (ATR-MIR-HOF) probe was home-built, which mainly consists of two HOFs and a newly designed conical frustum of ZnSe crystal. Compared to conventional Fourier transform infrared (FTIR) and ATR-FTIR imaging technique, ATR-HOF-FTIR could obtain reliable ATR IR spectra of samples without any sample pretreatment. ATR-HOF-FTIR detection of articular cartilage (AC) further demonstrates that the ATR-MIR-HOF probe is capable to easily detect in situ tiny target area and obtain effective spectral information on the changes in main constituents of AC with excellent repeatability. The probe is suitable for submillimetric detection in biochemical, biomedical areas and is potential for clinical diagnosis of osteoarthritis at different stages.
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