Abstract
Parkinson's disease (PD) is a common progressive neurological disorder and is composed of motor and non-motor symptoms. Sleep disturbances are frequent problems for patients with PD. The relationship between sleep disturbances with Hoehn and Yahr (H&Y) staging have been demonstrated. However, the relationship between sleep disorders and H&Y is still unclear in patients with PD without dementia in Chinese PD patients. In this study, we interviewed 487 non-demented PD patients of Chinese Han descents by H&Y classification. We found that night sleep quality was significantly associated with the severity of PD (P = 0.008). Panic disorder severity scale (PDSS) total scores were correlated with PD non-motor symptoms scale (PDNMS) scores (r = -0.528, P < 0.001), the Hamilton depression scale (HAMD) scores (r = -0.545, P < 0.001) and the Hamilton anxiety scale (HAMA) scores (r = -0.498, P < 0.001). Our results indicated that sleep quality deteriorated with the advancing of PD in Chinese non-demented patients with PD. Depression and anxiety may partly explain sleep disturbances in non-demented patients with PD.
Highlights
Parkinson's disease (PD) is a common progressive neurological disorder involving 1.7% of the geriatric population in China[1] and 2.0% of the elderly population globally[2], respectively
Instruments applied in the study for the assessment and rating. The neurologists made their evaluation by regular in-clinic follow-up visits and used the Hoehn and Yahr (H&Y) staging (Table 1)[10] to assess PD severity, the PD non-motor symptoms scale (PDNMS)[11] to assess PD non-motor symptoms, the PD sleep scale (PDSS)[9] to assess sleep quality, the Mini Mental State Examination (MMSE)[12] to assess cognition, the Hamilton depression rating scale (HAMD)[13] and the Hamilton anxiety scale (HAMA)[14] to assess the mood of patients
We interviewed 487 PD patients without dementia
Summary
Parkinson's disease (PD) is a common progressive neurological disorder involving 1.7% of the geriatric population in China[1] and 2.0% of the elderly population globally[2], respectively. Non-motor symptoms such as sleep disturbances and mood disorders are common in patients with PD. A correlation had been demonstrated in patients with PD from the USA[7] between sleep disturbances or mood disorders with Hoehn and Yahr (H&Y) staging, which classifies PD mainly by motor symptoms.
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