Subcutaneous Fat Necrosis of the Newborn

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AbstractThis is an image-based clinical vignette showing pathologic findings typical of subcutaneous fat necrosis of the newborn (SFNN). The infant—a 15-month-old girl—presented with indurated subcutaneous masses of unknown etiology. This case is a reminder that SFNN, while more common in the newborn period, can occur throughout infancy. It also reminds us that the rare metabolic disorder (Lesch–Nyhan syndrome) may be associated with lesions that can appear somewhat similar under the microscope.