Abstract
Superoxide dismutase (SOD), a naturally existing enzyme, acts as potent scavenger of reactive species. The beneficial effects of SOD have been displayed in treating radiation induced lung toxicities in animal models. For this study, we selected bSOD (bovine SOD) protein as it is inexpensive, easily synthesized, clinically administrable, stable, and least toxic at high doses. Therefore, the objective of this study was to determine whether subcutaneous administration of bSOD reduces the severity of long-term lung injury induced by thoracic irradiation (RT).
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