Abstract
The pineal regions of five human fetuses of 180–230 mm crown-heel lengths have been investigated in serial sections. Man possesses a subcommissural organ at these ages which has glandular properties and closely resembles that of most subhuman animals. The subcommissural secretion, which is discharged into the cerebrospinal fluid, does not, however, form a Reissner's fiber. The subcommissural epithelium is extensively distributed in the epithalamus, and it is found in the pineal diverticulum as well, where the cells have the same glandular properties. The posterior lobe of the pineal organ is apparently built up from this specialized ependyma, and there are signs that the ependymal cells may retain their secretory properties for some time in the developing pineal organ.
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