Abstract
Subclinical infection of vaccinated chickens with a highly pathogenic avian influenza A(H5N2) virus was identified through routine surveillance in China. Investigation suggested that the virus has evolved into multiple genotypes. To better control transmission of the virus, we recommend a strengthened program of education, biosecurity, rapid diagnostics, surveillance, and elimination of infected poultry.
Highlights
Subclinical infection of vaccinated chickens with a highly pathogenic avian influenza A(H5N2) virus was identified through routine surveillance in China
Highly pathogenic avian influenza (HPAI) among Vaccinated Chickens recent H5N1 HPAI viruses in clade 7.2, and the remaining 6 genomic segments of H5N2qd14 likely reassorted from subtype H9N2 avian influenza virus (Figure, online Technical Appendix Figures 1–7 [wwwnc.cdc.gov/EID/ article/20/12/14-0733-Techapp.pdf])
This study showed that H5N1 subtype HPAI virus has evolved into multiple H5N2 genotypes, which are all likely vaccine-escape variants, suggesting that this virus can evolve into vaccineescape variants
Summary
Subclinical infection of vaccinated chickens with a highly pathogenic avian influenza A(H5N2) virus was identified through routine surveillance in China. The entire viral genome of the virus, A/chicken/Qingdao/1/2014(H5N2), abbreviated as H5N2qd14, was sequenced and analyzed as described [4]. Phylogenetic analysis of the HA gene suggested that H5N2qd14 is a variant of clade 7.2 (Figure); this variant has become predominant in clade 7.2 in China since 2011 [5].
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