Abstract
<p><strong>Objective</strong>:<strong> </strong>The aim of this research was to evaluate the safety of <em>Costus speciosus</em> extract (CSE) after a 90-day administration in male mice.</p><p><strong>Methods</strong>:<strong> </strong>Sub-acute toxicity test was performed using the OECD 408 method. CSE at 275-1100 mg/kg/day was administered to male mice for 90 d. The appearance of toxic symptoms was observed every day, followed by measurement of food and drink intakes. Change in body weight, the result of a routine blood check and blood biochemistry were observed and statistical analysis was performed on them. Test animals were killed at the end of the study and the weights of vital organs were examined before organ histology was examined.</p><p><strong>Results</strong>:<strong> </strong>The research result showed that the administration of CSE at 275-1100 mg/kg/day for 90 d did not show any significant disturbance in all parameters, except for reductions of cholesterol and blood glucose levels of test animals (p&lt;0.05).</p><p><strong>Conclusion</strong>:<strong> </strong>The results obtained in this research indicated the safety of CSE as a candidate of standardized herbal medicine for male contraception.</p>
Highlights
Pacing (Costus speciosus) in India is used as a traditional medicine for various diseases, e. g. as anti-diabetic and anti-infective medicines
In Wawoni Island in Sulawesi, Pacing has been used as a traditional medicine to reduce fertility in men and women for a long time
The results revealed that the vital organs such as liver, heart, and kidney were not adversely affected throughout the treatment by Costus speciosus extract (CSE) (P>0.05)
Summary
Pacing (Costus speciosus) in India is used as a traditional medicine for various diseases, e. g. as anti-diabetic and anti-infective medicines. Pacing (Costus speciosus) in India is used as a traditional medicine for various diseases, e. In Indonesia, Pacing thrives in wet areas without care. Pacing is known as a wild plant belongs to family Costaceae, lately it is cultivated as a decorative plant. In Java, Pacing which grows wild in yards or riverbanks has not been utilized. In Wawoni Island in Sulawesi, Pacing has been used as a traditional medicine to reduce fertility in men and women for a long time. The part of Pacing which is usually used is the tuber [1]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pharmacy and Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
