Abstract
Abstract Objectives To explore the possible link between reproductive abnormalities among men and exposure of toxic chemicals in the environment. Methods The study investigated the sperm functions and the antioxidant defence system of rats exposed to leachate obtained from Elewi Odo municipal battery recycling site (EOMABRSL) via oral route. Results EOMABRSL had significant effects on both absolute and relative testicular weight. Formation of sperm abnormalities was observed following EOMABRSL exposure. Antioxidant enzymes including superoxide dismutase and catalase were significantly altered in the testes resulting into increased lipid peroxidation. Reduced glutathione (GSH) levels were found to be significantly ( P Conclusion The study concluded that possible mechanisms by which EOMABRSL at the investigated doses elicits spermatotoxicity could be linked to the testicular oxidative stress and damage to germinal epithelial cells by mixed-metal exposure. However, this may suggest possible reproductive health hazards in subjects with environmental or industrial exposure.
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