Abstract
collagenous band thickness, and lamina propria inflammation. Hazard ratios (HR) were calculated by logistic regression analysis with 95% confidence intervals. Results: The overall symptom relapse rate was 61%. By multivariate analysis, a baseline stool frequency >5/day (HR 3.95; 1.08 14.39), a history of diarrhea >12 months (HR 1.77; 1.04 3.03), and the absence of budesonide maintenance therapy (HR 2.71; 1.37 5.38) were associated with symptom relapse. The time to relapse was shorter in patients with a baseline stool frequency >5/day (56 vs. 199 days, p = 0.024), as in those with a history of diarrhea >12 months (56 vs. 220 days, p = 0.009). Budesonide maintenance therapy delayed the time to relapse (56 versus 207 days, p = 0.005). Conclusions: Our data demonstrate that a high stool frequency at baseline and a long duration of diarrhea are risk factors for symptom relapse in collagenous colitis, while budesonide maintenance therapy is a protective factor against symptom relapse.
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