Abstract
Biologically active substances (BAS) extracted from marine hydrobionts are characterized by high diversity and efficiency. They are represented by carotenoids, phospholipids, saponins and other compounds possessing high antioxidant (AOA), antitumor, immunomodulatory, radioprotective, and hypolipidemic activities. Because of extremely high marine BAS activity, the BAS dose necessary for treatment and prevention of many diseases is very small. The aim of present work was to assess biological properties of BAS complexes extracted from Black Sea marine inverterbrates for their following using in pharmacological preparations including liposomal drug delivery. BAS complexes were extracted from marine invertebrate tissues by two-phase extraction in combination with ultrasonication. Antioxidant activity of BAS extracts was determined with potassium permanganate discoloration method in an aqueous sulfuric acid medium. Antimicrobial activity was investigated by germination of BAS extracts. BAS influence on lymphocyte proliferative activity was studied with help of cytogenetic analysis. In this paper, the assessment of antioxidant, antimicrobial and mitogenic activities of biologically active complexes extracted from marine invertebrate tissues is presented. BAS properties in the oil and alcohol-water phases are compared. For the first time BAS complexes from Black Sea invertebrates are extracted by the resource-light method of two-phase extraction in combination with ultrasonication. Conditions for obtaining BAS extracts with optimal characteristics are proposed.
Highlights
The uniqueness of marine biologically active substances is associated with aqueous living environment of hydrobionts characterized by high salt content, low or no light, extremely low or high temperatures and high pressure
Marine hydrobionts are characterized by the diversity and high efficiency of biologically active substances
Complexes of biologically active substances were extracted from marine invertebrate tissues by two-phase extraction in combination with ultrasonication
Summary
The uniqueness of marine biologically active substances is associated with aqueous living environment of hydrobionts characterized by high salt content, low or no light, extremely low or high temperatures and high pressure. This ensures the difference between marine organisms and their metabolites from terrestrial ones. Marine hydrobionts are characterized by the diversity and high efficiency of biologically active substances. Hydrobionts of marine areas, especially invertebrates such as crustaceans, mollusks and echinoderms differ from many terrestrial and aquatic organisms in significant variety of metabolites The dominant part of these metabolites is represented by functional compounds: flavonoids, carotenoids, phospholipids, saponins, polyunsaturated fatty acids omega three and omega six and other substances possessing high antioxidative, antitumor, immunomodulatory, radioprotective, and hypolipidemic activities [1].
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