Abstract
BackgroundA frequent disorder after stroke is neglect, resulting in a failure to report or respond to contralesional stimuli. Rehabilitation of neglect is important, given the negative influence on motor recovery, independence in self-care, transfers, and locomotion. Effects of prism adaptation (PA) to alleviate neglect have been reported. However, either small groups or no control group were included and few studies reported outcome measurements on the level of activities of daily living (ADL). The current ongoing RCT investigates the short- and long-term effects of PA in a large population in a realistic clinical setting. Measures range from the level of function to the level of ADL.Methods/DesignNeglect patients in the sub-acute phase after stroke are randomly assigned to PA (n = 35) or sham adaptation (SA; n = 35). Adaptation is performed for 10 consecutive weekdays. Patients are tested at start of the study, 1 and 2 weeks after starting, and 1, 2, 4 and 12 weeks after ending treatment. Primary objectives are changes in performance on neuropsychological tests and neglect in ADL. Secondary objectives are changes in simulated driving, eye movements, balance, visual scanning and mobility, subjective experience of neglect in ADL and independence during ADL.DiscussionIf effective, PA could be implemented as a treatment for neglect.Trial registrationThis trial is registered at the Dutch Trial Register #NTR3278.
Highlights
A frequent disorder after stroke is neglect, resulting in a failure to report or respond to contralesional stimuli
If effective, prism adaptation (PA) could be implemented as a treatment for neglect
We aim to answer whether PA ameliorates neglect better and earlier compared to sham adaptation (SA)
Summary
A frequent disorder after stroke is neglect, resulting in a failure to report or respond to contralesional stimuli. Ten Brink et al BMC Neurology (2015) 15:5 long-term prism training has been reported to show long-lasting beneficial effects, from weeks [21,22,23,24] up to two years [25] after ending prism adaptation. Notwithstanding these positive results, either small groups or single cases were reported, no control group was included, and/or no measurements at the level of activities of daily living (ADL) were used
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