Study on the prognosis of propofol after reperfusion in patients with replantation surgery

Abstract

Objective To evaluate the influence of different concentrations of propofol on ischemia/reperfusion(I/R) replantation surgery prognosis of patients. Methods Ninety patients that had done replantation surgery were included. All patients were the ASA grade statusⅠor Ⅱ. Ninety patients were randomly divided into three groups(n=30), low concentration group (group L), high concentration group (group H) and control group(group C). All patients in all coracoid single point method brachial plexus, nerve stimulator to locate. Limb were compared in plasma malondialdehyde(MDA), ischemia modified albumin(IMA), concentration of superoxide dismutase(SOD) three indicators. Patients were followed up for a week after surgery were compared the incidence of vascular crisis and survival. Analyzed and summarized the prognosis of different concentrations of propofol anesthesia. Results One hour after anesthesia after tourniquet, the concentration of IMA and MDA in group H and group L were both significantly lower than group C, compare with a significant difference(P<0.05), SOD value in group H after 1 h and L group was significantly lower(P<0.05). After a week of follow-up found that the incidence of vascular crisis in H group and group L were significantly lower than group C, compare with a significant difference[χ2(LC)=4.523, P(LC)=0.033, χ2(HC)=9.871, P(HC)=0.005]. The survival in group H and group L were both significantly higher than finger group C, compare with a significant difference[χ2(LC)=3.857, P(LC)=0.049, χ2(HC)=6.857, P(HC)=0.009]. Conclusions The propofol has played a very good anaesthesia effect in ischemia/reperfusion (I/R) , propofol can improve the survival rate after replantation of I/R, and high concentration of propofol can better improve the prognosis. Key words: Replantation; Propofol; Ischemia/reperfusion