Abstract
As a common immune disease, food allergy has become a difficult problem for public health organizations. Food allergies are often accompanied by skin reactions, allergic rhinitis, gastrointestinal diseases, and other complications which can induce anaphylactic shock and even death. However, mechanisms underlying food allergies are not fully understood. Therefore, exploring the mechanism of induction of food allergy is a critical first step toward discovering a future treatment. Here we constructed a quercetin–chitosan nanoplasmid (QT–CS NPs), which can regulate the balance of Th1/Th2 cells, and used it to treat ovalbumin (OVA)-induced allergies in mice. The results suggest that compared to natural quercetin, the cytotoxicity of QT–CS NPs was weakened. QT–CS NPs also increased the expression of the Th1 cytokine INF-γ, reduced the secretion of Th2 cytokine IL-4, regulated the balance drift of Th1/Th2 cells in allergic mice, and demonstrated an excellent immunomodulatory effect. Therefore, QT-CS NPs can provide new treatment ideas for the prevention and treatment of food allergy, and this study can lay an experimental foundation for the clinical application of QT-CS NPs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
