Abstract
Ethyl cyanoacetate is an important chemical intermediate and has been used widely. Ethyl cyanoacetate was prepared by esterification of cyanoacetic acid and absolute ethanol with mixed catalyst (the same proportion of silicotungstic and p-toluene sulfonic acid as catalyst). The influence factors of the amount of catalyst, n(cyanoacetic acid): n ( absolute ethanol), reaction time and reaction temperature on the esterification rate was investigated by orthogonal experiment of four factors and three levels. The product was analyzed by gas chromatography to determine the optimum reaction conditions.
Highlights
Ethyl cyanoacetate molecular formula is C5H7NO2 and structural formula is NCCH2COOCH2CH3
Cyanoacetic acid, absolute ethanol and catalyst were added into four-necked flask and stirred with an electric agitator to make the evaporated water and absolute ethanol flow back to the water separator through the condensing pipe.Gas chromatography analyzer was used for analysis and internal standard method was used for calculation
Benzene was used as the internal standard, 99% pure ethyl cyanoacetate was used as the reference substance.The correction factor was calculated, and the correction factor was used to calculate the content of ethyl cyanoacetate prepared
Summary
Ethyl cyanoacetate molecular formula is C5H7NO2 and structural formula is NCCH2COOCH2CH3. Ethyl cyanoacetate was prepared by esterification of cyanoacetic acid and absolute ethanol.
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