Study on Infertility—Etiology, Medication Therapy Management, and Outcomes at a Tertiary Care Hospital

Abstract

ABSTRACT Aim The aim of the article is to study infertility—etiology, medication therapy management, and outcomes in a tertiary care hospital. Objectives The purpose of this study was to compare the outcomes of standard aetiology wise treatment protocols of infertility and the various causes which may be a contributing factor to infertility. Materials and methods A prospective observational study was conducted for 6 months at a tertiary care hospital. Couples diagnosed with infertility, aged 18 to 49 years were enrolled in the study. Details like couple's sociodemographic data, etiology, risk factors associated with infertility, management with current medications, procedures, and outcomes were documented using predesigned infertility proforma. Results Females had an age group of 19 to 38 years with an average age and standard deviation (SD) of 25.64 ± 4.07 years, whereas male patients had an age of 24 to 43 years with a mean age and SD of 30.59 ± 4.17 years. Primary infertility was 59.13% and secondary infertility 40.86%. In women with infertility, ovulatory disorders were the chief cause, followed by unexplained factor, uterine tubal, and more than one cause, whereas in males semen abnormalities were the major cause of both primary and secondary infertility, followed by unexplained, anatomical, more than one cause. Medical therapy involving drugs like clomiphene, gonadotropins, and a combination was administered to females. Males received lycopene, L-carnitine, ubidecarenone, zinc, and astaxanthin. Intrauterine insemination (IUI) was performed in 28 patients. From the available data of 100 couples undergoing management for infertility in the 6 months study period, 19 patients conceived, i.e., 19% showed conception. Conclusion The present study shows etiological and pathological causes of infertility. The study highlights positive results with standard treatments. Clinical significance To identify hidden social, medical, pathological, and other confounding causes leading to infertility. How to cite this article Khanuja PK, Sunny JA, Pawar SB, Nimbargi V. Study on Infertility—Etiology, Medication Therapy Management, and Outcomes at a Tertiary Care Hospital. Int J Infertil Fetal Med 2017;8(3):106-112.