Abstract
目的 了解丙型肝炎患者DC-SIGN/DC-SIGNR基因颈区重复序列的遗传多态性分布,探讨DC-SIGNR基因多态性与丙型肝炎病毒(HCV)载量的关系.方法 采用PCR结合DNA测序对300例丙型肝炎患者DC-SIGNR重复序列多态性进行基因分型和测序分析;同时检测了患者的HCV病毒载量.结果 该研究发现携带7等位基因(中等的)的患者,其HCV病毒载量水平低于携带9等位基因(较长的)的患者(P＜0.05),此外7/7基因型的患者组其HCV病毒载量水平低于9/7基因型的患者组,两组的差异有统计学意义(P＜0.05),提示HCV病毒更易与携带较长DC-SINGR等位基因的患者结合.结论 DC-SIGNR遗传多态性可能与HCV病毒在个体内的复制有关。
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