Abstract
Hepatic injury and its associated conditions have been reportedly shown to be managed through herbal remedies. In this study, investigation of the fresh leaf aqueous extract of Flacourtia indica (of the family of Salicaceae) as hypoglycemic, anti-anemic and hepatoprotective agent in albino wistar rats induced CCl4 hepatotocxicity was done. Fifteen rats of either sex, weighing 175-295g, divided into five groups (I-V) of three rats each, were used. Group-I is negative control, II-positive control and III –V test groups. Groups II-V were induced 200mg/Kg/bodyweight CCl4, for 3-days, for hepatic injury and anemia. Groups III-V were respectively treated orally with 400, 600 and 800 mg/Kg/bodyweight of fresh leaf aqueous extracts (FLAE) of Flacourtia indica, for 7-days. Activities of Alanine aminotransferase, Aspartate aminotransferase, Alkaline phosphatase, concentrations of Bilirubin, Albumin, Total protein, blood glucose and packed cell volume (PCV) and hemoglobin were assayed. Results after induction showed significant (p˂0.05) decrease in heamoglobin and PCV, significant (p˂0.05) increase in the liver function enzymes and blood glucose compared with results of liver function enzyme and blood glucose having significant (p˂0.05) decrease, and significant (p˂0.05) increase of PCV and hemoglobin after treatment with FLAE of Flacourtia indica. Body weight of rats induced CCl4 was found to increase with FLAE of Flacourtia indica treatment. It may be concluded that the potentials exhibited by FLAE of Flacourtia indica to manage hyperglycaemia, hepatic injury and anemia induced by CCl4 are associated with its antioxidant activity and the presence of phytochemicals, minerals and nutrients value.
Highlights
Plants have been largely used in the quest of managing health challenges as alternative of nature’s providence
The packed cell volume (PCV) and hemoglobin of rats after induction with CCl4 and after treatment with Fresh Leaf Aqueous Extract (FLAE) of Flacourtia indica for seven (7) days is shown in table 3
There was significant (p
Summary
Plants have been largely used in the quest of managing health challenges as alternative of nature’s providence. Phytochemicals are chemicals in plants with no nutritive value but highly effective in disease prevention and protection when consumed. Most of these bioactive plants’ compounds have been implicated in the treatment, management and prevention of ailments. Flacourtia indica’s leaf, stem bark, fruits and root like other plants, is not exempted from these beneficial characteristics These have been shown to possess biological, medicinal and pharmacological potentials in the prevention and treatment of hepatic disease[3], cardiovascular diseases, cancer[5], diabetes[6], bacterial infection[1], and other conditions like anemia hyperglycemia and hypercholesterolemia[7,8]. Various researchers have demonstrated that plants are rich sources of antioxidant vitamins such as vitamins A, C and E4, minerals such as Fe, Mg, Mn, N, P, Ca, Na and K9 and phytochemicals such as phenolics (tannins, flavonoids), carotenoids, anthocyanins, coumarin
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