Abstract
Street food is one of the major causes of diarrhoea and gastrointestinal infections. Escherichia coli are one of the major contributors for many gastrointestinal infections. Natural sources are used to derive drugs that play striking role in the prevention and treatment of human diseases. Ayurveda has described Earandakarkati (Carica papaya) in many digestive disorders. This study was carried out to show the antimicrobial activity of Erandakarkati (Carica papaya) leaves extract alone and in combination with the antibiotics including Penicillin, Erythromycin, Piperacillin and Norfloxacin using agar strip diffusion method to see whether they produce synergistic or an antagonistic effect against street food isolated Escherichia coli and diarrhoeal ETEC strain (as a control). Carica papaya leaves extract showed antibacterial effect. The only combination of papaya leaf extract with Piperacillin resulted into a synergistic effect while the other combinations exhibited an antagonistic effect.
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