Abstract
Hemato-ophthalmic barrier is one of the mechanisms of body resistance. One of the complications of mechanical trauma of the eye and violation of the hemato-ophthalmic barrier is the emergence of oxidative stress on the background of the general inflammatory process. Normally, oxidative stress in the skeletal muscle tissue is not a damaging agent, but when intensified by other factors, it promotes pathological changes in the body. Objective: to study the dynamics of superoxiddismutase (SOD) activity in rat skeletal muscle tissue under oxidative stress caused by mechanical action on the hemato-ophthalmic barrier. Materials and methods: The study was carried out on pedigree matured male rats in the amount of 150 pieces. The activity of SOD in skeletal muscle tissue was studied before the experiment, as well as on the 1st, 3rd, 5th, 7th and 14th day of the experiment using the standard technique of V.S. Gurevich. The obtained digital material was subjected to statistical processing by means of non-parametric statistical analysis. Conclusion: SOD activity in rat skeletal muscle tissue under oxidative stress caused by mechanical action on hemato-ophthalmic barrier is most effectively stabilized in standard therapy of mechanical eye injury with the addition of quercetin in the form of injections.
Highlights
Hemato-ophthalmic barrier is one of the mechanisms of resistance, which serves to protect the body and prevents homeostasis disorder when the body is affected by factors that can disturb this balance
The purpose of our study was to study the dynamics of superoxiddismutase activity in rat skeletal muscle tissue under oxidative stress caused by mechanical action on the hemato-ophthalmic barrier
In the 4th group of rats with induced oxidative stress and its elimination by standard therapy of mechanical eye injury with addition of quercetin a less intensive decrease of SOD activity was observed up to 7 days of experiment, and by the 14th day the enzyme activity corresponded to physiological norm, though it did not reach the initial value
Summary
Hemato-ophthalmic barrier is one of the mechanisms of resistance, which serves to protect the body and prevents homeostasis disorder when the body is affected by factors that can disturb this balance. It regulates the entry into and removal from the eye of various substances typical of normal and pathological metabolism, and it performs an immune function, preventing the penetration of microorganisms, antibodies and leukocytes [1]. Muscle contraction in general leads to the formation of free-radical products with a speed determined by the specificity, intensity, frequency and duration of physical activity [10]
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