Abstract
99mTc is the most applied medical radioisotope in the world, especially for cancer diagnosis procedures. It is provided by 99Mo radioactive decay, which is one of the fission products from the uranium irradiation in nuclear reactors. At the main production plants, the 99Mo chemical processing may be lined up in several steps to separate it from other fission products according to the features of the used targets or the local requirements as well. In this work, two routes of 99Mo purification, MR1, and MR2, were purposed as an alternative to be set up in the Brazilian Multipurpose Reactor project (BMR). The MR1 route was performed by three chromatographic columns packed with Dowex 1x8 resin, Chelex resin, and alumina, respectively. The route MR2 was carried out also by chromatography applying two columns filled with Dowex 1x8 and alumina respectively, but including a sublimation process performed in a tubular oven under programmed conditions. The final yield for the MR1 route was 84.4 % and the overall time process was about 7 hours, whereas the MR2 route reached 75.3 % in 9 hours.
Highlights
Nowadays, 99mTc is the main radioisotope used in nuclear medicine worldwide due to its pure gamma decay of low energy (140 keV) and short half-life (6.02 hours)
The results indicated that after the initial 99Mo separation on anionic resin column, only two more chromatographic columns were sufficient for satisfactory purification of this radioisotope
The ion exchange technique using an anionic resin column was applied in MR1and MR2 as the initial process step to purify the alkaline solution as adopted in the process adopted in Argentina and South
Summary
99mTc is the main radioisotope used in nuclear medicine worldwide due to its pure gamma decay of low energy (140 keV) and short half-life (6.02 hours). More than 22 million medical procedures are performed annually for diagnostic imaging tests applying 99mTc [3]. 99mTc can be provided for medical centers throughout the country using 99Mo/99mTc generators. The bulk 99Mo is divided and shipped to generators manufacturing units [4,5]
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