Abstract
Introduction: Polycystic ovarian syndrome is the most common endocrinopathy in the women of reproductive age with a prevalence of approximately 7-10 % worldwide. It reflects multiple potential aetiologies and variable clinical manifestations. This syndrome is characterised by serious health implications such as diabetes, coronary heart disease and also leads to infertility.Methods: Magnesium, uric acid, fasting blood sugar were estimated in 80 clinically diagnosed patients of PCOS who were between the age group of 18-40 years. Results were compared with a group of 40 normal subjects having same age group.Results: In our study, fasting blood sugar levels were significantly increased and serum magnesium levels were significantly decreased in PCOS patients suggesting increased urinary excretion of magnesium in the presence of elevated insulin. Magnesium showed a significantly negative correlation with FBS, TC, TGL, LDL, uric acid and non-significant positive correlation with HDL. Serum uric acid levels were significantly increased and showed significant positive correlation with FBS, TC, TGL, LDL and VLDL & significant negative correlation with magnesium.Conclusion: Administration of magnesium is acts as a beneficial effect on dyslipidaemia of PCOS patients by through the activation of LCAT and suppression of adrenergic activity. So, magnesium acts as a prognostic biomarker in PCOS patients.
Highlights
Polycystic ovarian syndrome is the most common endocrinopathy in the women of reproductive age with a prevalence of approximately 7-10 % worldwide
It reflects multiple potential aetiologies and variable clinical manifestations. This syndrome is characterised by serious health implications such as diabetes, coronary heart disease and leads to infertility
Women with polycystic ovarian syndrome (PCOS) are known to be at increased risk of insulin resistance
Summary
Polycystic ovarian syndrome is the most common endocrinopathy in the women of reproductive age with a prevalence of approximately 7-10 % worldwide It reflects multiple potential aetiologies and variable clinical manifestations. This syndrome is characterized by serious health implications such as diabetes, coronary heart disease and leads to infertility. Serum uric acid levels were significantly increased and showed significant positive correlation with FBS, TC, TGL, LDL and VLDL & significant negative correlation with magnesium. Hispanic women, migrant Asian Indians & Mexican Americans have a great prevalence of PCOS This syndrome is characterised by serious health implications such as diabetes, coronary heart disease and leads to infertility. These criteria are anovulation, androgen excess and polycystic ovarian morphology in ultrasound assessment [4]
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