Abstract
Objectives To analyze the protein expression and identify the localization of cellular markers related to the epithelial-mesenchymal transition process in salivary gland tumors. Study Design The expression and localization of E-cadherin, N-cadherin, SLUG, SNAIL, and TWIST were evaluated using immunohistochemistry in 48 salivary gland tumors: 17 pleomorphic adenomas, 14 cystic adenoid carcinomas (CAC), 17 mucoepidermoid carcinomas (MEC), as well as in 7 samples of normal gland tissue. Results A low expression of E-cadherin was observed in most of the evaluated tumors and a high expression of N-cadherin in malignant tumors but without statistical significance. In addition, there were statistically significant differences in the expression of SNAIL (P = .03), SLUG (P = .03), and TWIST (P = .01) in the tumor parenchyma of the MEC, as well as a high expression of the SNAIL (P = .02) in the parenchyma cases of CAC. Conclusions We observed changes in the expression of protein markers, especially SNAIL, SLUG, and TWIST, in the evaluated malignant tumors. These transcription factors are important in the epithelial-mesenchymal transition process and are possibly related to the development of a more invasive tumor phenotype. To analyze the protein expression and identify the localization of cellular markers related to the epithelial-mesenchymal transition process in salivary gland tumors. The expression and localization of E-cadherin, N-cadherin, SLUG, SNAIL, and TWIST were evaluated using immunohistochemistry in 48 salivary gland tumors: 17 pleomorphic adenomas, 14 cystic adenoid carcinomas (CAC), 17 mucoepidermoid carcinomas (MEC), as well as in 7 samples of normal gland tissue. A low expression of E-cadherin was observed in most of the evaluated tumors and a high expression of N-cadherin in malignant tumors but without statistical significance. In addition, there were statistically significant differences in the expression of SNAIL (P = .03), SLUG (P = .03), and TWIST (P = .01) in the tumor parenchyma of the MEC, as well as a high expression of the SNAIL (P = .02) in the parenchyma cases of CAC. We observed changes in the expression of protein markers, especially SNAIL, SLUG, and TWIST, in the evaluated malignant tumors. These transcription factors are important in the epithelial-mesenchymal transition process and are possibly related to the development of a more invasive tumor phenotype.
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