Abstract
Somatomedins (Sms) are the mediators of growth hormone (GH) on peripheral tissues. Other hormones are playing role in their synthesis, particularly insulin, prolactin (PRL) and estradiol. This work was planned to interrelate the GH, PRL and Sm-C in adult-onset obese young males. Fifty five obese males (25 ± 5.09 years, means ± SDM) with body mass index (BMI) 32.8 ± 3.5 kg/m2, as well as 20 lean age matched males with BMI 22.9 ± 1.31 kg/m2 were chosen for the study. Morning fasting serum levels of GH, PRL and Sm-C were estimated by RIA. The obese group was classified according to Sm-C levels into 3 groups: low Sm-C level, an intermediate level within the range of the control and with higher serum Sm-C levels. Serum GH was low in all groups. The variability of Sm-C might be associated with hyperinsulinaemia characterising obesity, or altered nutritional status of the individual subjects. Significant positive correlation coefficient was found between serum Sm-C and BMI.
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