Abstract
Cervical cancer is the third most prevalent cancer in women worldwide, and the fourth leading cause of death from cancer in women. Recent advances, such as the availability of broad scale genome data, articulated gene tag (EST) data bases, innovative sequence alignment techniques, and X-ray crystallography determination of three-dimensional structures, have significantly expanded our understanding of structure–function relationships in this important enzyme superfamily. Total 36 histologically confirmed patients, locally advanced FIGO stage IIB–IIIB cervical cancer were enrolled. Based on the findings of our research, it can be concluded that improvements in GSH concentration during the treatment of locally advanced cervical cancer can have a major impact on the treatment response. In comparison to the lack of concentration changes in the blood serum of patients who have had no reaction to medication or who have had a reported relapse following treatment, GSH tends to be an effective indicator.
Highlights
It is well understood that glutathione-stransferase (GST) play an important role in step II of enzymatic detoxification
Patients were split into two groups to evaluate improvements in GSH and GST concentrations in response to neoadjuvant chemotherapy (NACT) therapy based on a mixture of cisplatin and gemcitabine: one group (n = 26) had a supportive response to the treatment, while the other group (n = 10) had no response
During the care of patients who did not respond to NACT, there were no major differences in GST and GSH concentrations (Table 2)
Summary
It is well understood that glutathione-stransferase (GST) play an important role in step II of enzymatic detoxification. Recent advances, such as the availability of broad scale genome data, articulated gene tag (EST) data bases, innovative sequence alignment techniques, and X-ray crystallography determination of threedimensional structures, have significantly expanded our understanding of structure– function relationships in this important enzyme superfamily. Nonmammalian GSTs have a disproportionately high number of crystal structures. The classification of non-mammalian GSTs is the subject of this study, which focuses on their importance in expanding our understanding of structure– function relationships in these enzymes as well as the implications for the evolution of this dynamic multifunctional superfamily [1]
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