Abstract
The objective: to assess the elution characteristics of anti-tuberculosis drugs (isoniazid, cycloserine, rifampicin, amikacin, kanamycin, ethambutol) placed into bone cement samples and put in a liquid medium to determine the possibility of using such systems as a drug reservoir.Subjects and methods. For in vitro studies, pure substances of the drugs were used. The spectrophotometry was used to study the elution kinetics of the drugs. Absorption spectra of the drugs in the visible and ultraviolet regions were analyzed to reveal the absorption maxima, and the resistance of the chemical structure of the drugs to heating was assessed. Further, the changes of drug release from hardened bone cement samples under static conditions were studied.Results. It has been found that studied drugs demonstrated satisfactory parameters of thermal stability and elution which makes it possible to use them in a mixture with bone cement.
Highlights
Цель исследования: оценка элюционных характеристик противотуберкулезных препаратов, загруженных в образцы костного цемента и помещенных в жидкую среду для определения возможности использования подобных систем в качестве депо препарата
Study of elution characteristics of anti-tuberculosis drugs mixed with bone cement
Traumatologist and Orthopedist of ExtrapulmonaryTuberculosis Unit Department. ФГБОУ ВО «Российский химико-технологический университет им. Д. И. Менделеева» Минобрнауки РФ, 125047, Москва, Миусская пл., д. 9. Тел.: + 7 (499) 972-48-08. Mendeleev University of Chemical Technology, 9, Miusskaya St., Moscow, 125047. Phone: +7 (499) 972-48-08. Артюхов Александр Анатольевич профессор кафедры биоматериалов. Professor of Biomaterials Department. Штильман Михаил Исаакович профессор кафедры биоматериалов
Summary
Pure substances of the drugs were used. The spectrophotometry was used to study the elution kinetics of the drugs. Absorption spectra of the drugs in the visible and ultraviolet regions were analyzed to reveal the absorption maxima, and the resistance of the chemical structure of the drugs to heating was assessed. The changes of drug release from hardened bone cement samples under static conditions were studied
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