Study of Cyclohexane and Methylcyclohexane Functionalization Promoted by Manganese(III) Compounds

Abstract

Alkane functionalization using safe and low-energy processes is of great interest to industry and academia. Aiming to contribute to the process of saturated hydrocarbon functionalization, we have studied a set of three manganese(III) complexes as catalysts for promoting the oxidation of saturated hydrocarbons (cyclohexane and methylcyclohexane) in the presence of hydrogen peroxide or trichloroisocyanuric acid (TCCA). The mononuclear manganese(III) compounds were prepared using the ligands H2LMet4 (6,6’-((1,4-diazepane-1,4-diyl)bis(methylene))bis(2,4-dimethylphenol), H2salen (2,2’-((1E,1’E)-(ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene))diphenol) and H2salan (2,2’-((ethane-1,2-diylbis(azanediyl))bis(methylene))diphenol). The catalytic processes were carried out in acetonitrile at 25 and 50 °C for 24 h. The increase in the temperature was important to get a better conversion. The compounds did not promote cyclohexane oxidation in the presence of H2O2. However, they were active in the presence of TCCA, employing a ratio of 1000:333:1 equivalents of the substrate:TCCA:catalyst. The best catalytic activity was shown by the compound [Mn(salen)Cl], reaching conversions of 14.5 ± 0.3% (25 °C) and 26.3 ± 1.1% (50 °C) (yield for chlorocyclohexane) and up to 12.1 ± 0.5% (25 °C) and 29.8 ± 2.2% (50 °C) (total yield for the mixture of the products 1-chloro-4-methylcyclohexane, 3-methylcyclohexene and 1-methylcyclohexene). The interaction of the catalysts with TCCA was studied using electron paramagnetic resonance (EPR), suggesting that the catalysts [Mn(LMet4)Cl] and [Mn(salan)Cl] act via a different mechanism from that observed for [Mn(salen)Cl].