Abstract
An unusual opportunity to study the lipid composition of various tissues in an extremely rare condition, that of generalized lipodystrophy, was offered when death occurred in a 9-year-old boy in whom an almost complete absence of adipose tissue from the body had been present for the past 6 years (Case 1). In addition to this remarkable apparent lack of body fat, the symptom complex was composed of cirrhosis of the liver, chronic fibrosis of the spleen, pancreas and certain lymph nodes, and diabetes mellitus. Necropsy was begun within one hour following demise, at which time samples of various tissues were obtained. After being weighed, the specimens (usually about 1 g of tissue) were placed in 95% alcohol and allowed to stand for 24 hours. The tissues were then ground with sea sand in a mortar, rinsed several times with alcohol and ether, returned to the original flasks, and sufficient ether added to make approximately a 3:1 alcohol-ether mixture. The flasks were immersed in a boiling water bath for about...
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