Study of central venous oxygen saturation monitoring applicated in fluid resuscitation of patients with severe sepsis and septic shock

Abstract

Objective To guide the fluid resuscitation in patients with severe sepsis and septic shock by monitoring the central venous oxygen saturation(ScvO2), and to improve the rescue success rate and prognosis of patients with sepsis. Methods Based on the standard of ScvO2 of 6h, 45 patients with severe sepsis and septic shock were divided into two groups: observation group(n=28) and control group(n=17). The ScvO2, mean arterial pressure(MAP) and central venous pressure(CVP) levels were measured in the two groups after fluid resuscitation, and then the mortality, MAP compliance rate and CVP compliance rate were compared between the two groups. Results Compared with mortality in the control group(52.94%), the mortality in the observation group(14.29%) was significantly lower, the difference was significant (χ2=5.927, P=0.015), but after 6h's fluid resuscitation, the MAP and CVP standard number in the two groups did not exist significant difference(χ2=1.182, P>0.05). Conclusion ScvO2 with or without reaching the standard level(more than 65%) was positively correlated with the severity of the disease after fluid resuscitation in patients with severe sepsis and septic shock.Therefore, the monitoring of ScvO2 plays an important role in guiding the treatment of fluid resuscitation and judging the prognosis. Key words: Sepsis; Shock, Septic; Resuscitation