Abstract
The scope and limitations of the Pauson–Khand reactions of alkynyl sulfoxides with strained alkenes have been studied. ( S)-1-Hexynyl p-tolyl sulfoxide and ( S)-2-phenylethynyl p-tolyl sulfoxide afforded β-( p-tolylsulfinyl)enones in moderate yields and low diastereoselectivities. The diastereomeric mixtures were easily separated by column chromatography and the sulfinyl group could be cleaved by a sequence involving reduction to sulfide, carbonyl reduction and enol thioether hydrolysis to afford 1,3-rearranged enantiomerically enriched α-butyl and α-phenyl enones. The absolute configuration of the Pauson–Khand adducts was determined by X-ray diffraction. The decreased enantiomeric excess of the final products uncovered an unprecedented low temperature racemization of the hexacarbonyl dicobalt complexes of alkynyl sulfoxides.
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