Abstract
The effects of the species specific hypoglycaemic agent, cyclopropanecarboxylic acid, on gluconeogenesis in rat and guinea-pig kidney slices were investigated. Cyclopropanecarboxylate (0·1 mM) inhibited glucose production from pyruvate by 86 per cent in guinea-pig but by only 22 per cent in rat. ATP levels in guinea-pig kidney slices were decreased by Cyclopropanecarboxylate, but by an amount insufficient to account totally for the inhibition of gluconeogenesis. The site of inhibition of gluconeogenesis in guinea-pig kidney cortex slices was found to be located at the level of fructose-l,6-diphosphatase. Cyclopropanecarboxylate had no effect on partially purified FDPase and no detectable effect on gluconeogenesis in kidney homogenates. The mechanism of the Cyclopropanecarboxylate inhibition of gluconeogenesis is discussed, together with its possible hypoglycaemic action.
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