Abstract
An investigation of the antimicrobial activity and its concentration dependence of some pharmaceutical compounds other than preservatives (mercuric oxycyanide (MO), ethyl alcohol (EA), propylene glycol (PG) and sodium metabisulphite (SM)) has been performed. For this purpose the kinetic approach to the screening of antimicrobial activity of preservatives was successfully applied. D-values and concentration exponents (η) were used as parameters in determining microbiocidal activity. Aspergillus niger, Candida albicans, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were employed as challenge organisms. All the substances tested exerted antimicrobial activity within the concentration ranges usually applied in pharmaceutical preparations. EA and PG had about the same η-value (3–6), while SM and MO had values of 1–2 and 0.4–3, respectively.
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